I always cry at the end of Les Mis. The intense sense of loss and betrayal I always feel when Valjean stops visiting Cosette, when his walks get shorter and shorter, is suddenly followed up by that climax of redemption, and the combination is just too much for me.
The other one that does it for me is A Prayer for Owen Meany:
And of course the ending gets to me. Not the actual death scene. But the way Irving built Future John's character, his bitterness, his hatred for an entire country, his sense that nothing really matters anymore, it all comes together for me in just that last line: "O God, please give him back! I shall keep asking you." And I get this sense of what an empty person John is now, and just how much Owen meant to him and to everyone.
So yeah. What in books has made you cry, specifically or in general?