.............or simply that love is not a game, much less about dominance, with an easy solution able to be solved by a computer.http://xkcd.com/55/
Obviously what the computer says is meant to be taken seriously. The comic character acknowledges the computer's views and decides to play another 'game' because he truly believes the 'game' of love only ends negatively, just as the computer says.
If the character (and therefore us) was meant to believe that the computer was incapable of understanding the analysis, the character would've responded in a way that contradicted what was suggested to him. Instead, he goes along with it and plays a game that he CAN win at, supposedly unlike 'love.'
I wish I could stop putting quotation marks around 'game' and 'love,' but Randall has really fucked up ideas about love (especially since 4 our of the last 7 comics were explicitly about sex or masturbation), and the idea of love being a game is just a plot device. He makes love a 'game' because games are usually won or lost, which is less complex than the possible outcomes of love. He's basically just asking the computer about whether or not seeking a relationship will result in happiness. The computer responds that if he seeks a relationship, it will fail and he will be unhappy. The computer adds that if he does not seek a relationship, he will also be unhappy.
Randall is not talking about a game, he is just using the concept of a game to make it easier to talk about the success or failure from seeking a partner. He is, however, being serious when he says that both seeking and withdrawing from love will cause unhappiness. If Randall wasn't making a serious statement, the man wouldn't have taken the computer's analysis as truth and decided to 'play another game.' The stick man was interested in the 'game of love' at the beginning of the comic, and the only reason given for why he was uninterested at the end was that he was told that he would always 'lose' and he took that information SERIOUSLY.