If your mind drifts toward Ebola, the BBC has reading material.http://www.bbc.com/news/world-africa-28754546
Five from Scotland are there.http://www.bbc.com/news/uk-scotland-30158305
From London thirty are on their way.http://www.bbc.com/news/health-30148979
(oh, sniff-sniff) One of the people flying out came from Sierra Leone.
Another one lived there as a child. They are going Home to help.
The Drugs. The Vaccines.
Are you getting enough information?
Tobacco Plants. They say Tobacco Plants will save us all.http://www.webmd.com/news/20140804/ebola-virus-vaccine
That did not tell me how to make that stuff or how exactly it works.
It Did tell me something I did not know.
Thomas Geisbert, MD, professor of infectious disease at The University of Texas Galveston Medical Branch, has been studying the Ebola virus since 1988.
That man said this.
“If we can prove that whatever the treatment was worked, that’s fantastic,” he says. “That’s exciting. But I’m cautiously optimistic, because with this particular outbreak, almost 40 percent of patients survive without treatment. So we want to make sure that it wasn’t somebody that was going to survive anyway."
40 percent survival??
It beats the snotty out of Ten Percent!
Another little Ebolia tid-bit.
It’s rare, but the Ebola virus can stay in semen for 3 months after a man recovers, so he should avoid sex or use a condom to keep from infecting others.
Survivor's get a new lease on life.
No one enjoys sex like a survivor.
Get those Condoms Out!
I've got Ebolia on The Brain.http://www.nationaljournal.com/health-c ... s-20141029
That link is basic vaccine stuff, for anyone that wants to review it. Wikipedia is probably better. (shrug)
There has been some serious work done.http://jvi.asm.org/content/77/18/9733.full
I don't know where to look for the date published.
This paper is old by science standards.
We may be closer to a cure, today.
Still; It is clear and it explains things well.http://jvi.asm.org/content/77/18/9733.full
(same link. don't ask)
Through this interaction, sGP may contribute to immune evasion by inhibiting early steps in neutrophil activation (as measured by the down-modulation of L-selectin) that would ordinarily assist in virus clearance
They know how it knocks out a natural response.
That's nice, I suppose.
Mr. Peabody's way back machine.
virion envelope glycoprotein (GP)
It's simply the sugary protein shell that causes most of the trouble.
What else has a shell that causes loads of trouble?
A bacteria that children get....darned.
Gram Negative cell walls kill... I don't remember. Do you?
Back to the article.
Analogous coiled-coil regions have been defined for GPs of influenza virus, murine retroviruses, HIV, and simian immunodeficiency virus (SIV) as well as for some cellular proteins, called SNARES, that function in intracellular vesicle fusion (44). For HIV gp160, it has been possible to identify peptides that bind to a transient intermediate form that precedes hairpin formation. Because of their potent inhibition of viral entry, these reagents have shown considerable promise in clinical trials (21). The Ebola virus GP contains a homologous hairpin structure for which a possible inhibitory peptide has been identified (43), a region that remains a potential therapeutic target.
It works for HIV. (right?)
No. I don't understand the reagents.
I am so glad there are smart, doggedly patent people out there.
ok. Finely a clear statement about use of survivor's blood.
however, anecdotal reports have indicated that serum from recovered patients did not consistently protect against infection or exhibit neutralization of virus replication in cell culture. Furthermore, passive transfer of antibodies in animal models only delays the onset of symptoms and does not alter overall survival
Still...An inconsistent transfer of antibodies is better than no transfer.
More recently, the neutralization of virus replication by selected monoclonal antibodies isolated from the bone marrow of recovered patients was demonstrated in vitro (24), and monoclonal antibodies that recognize specific epitopes of Ebola virus GP have been shown to confer immune protection in a murine model of Ebola virus infection
You survive Ebolia. Whew Hew!
You get to give Bone Marrow.
If you are a Rat!
Would you do it?
If you were the clinician; Would you do it?
If you were the donor; Would you do it?
It seems Booster Shots work.
Priming-boosting immunization protocols that use DNA immunization followed by boosting with poxvirus vectors carrying the genes for pathogen proteins have yielded dramatically enhanced immune responses in animal studies, with 30-fold or greater increases in antibody titer from the booster
Come on, you guys.
Recently, an accelerated vaccination has been developed that confers protection against a lethal virus challenge in nonhuman primates after a single immunization (36a). If this vaccine works similarly in humans, it may be useful in the containment of acute outbreaks by ring vaccination.
They have darned near Got It!
But...But..We don't know it is safe in Humans...
We Know Ebola w/o vaccine is not safe for Humans!
Was that fun?
OK. It's your turn.
You read one.
Life is, just, an exchange of electrons; It is up to us to give it meaning.
We are all in The Gutter.
Some of us see The Gutter.
Some of us see The Stars.
by mr. Oscar Wilde.
Those that want to Know; Know.
Those that do not Know; Don't tell them.
They do terrible things to people that Tell Them.